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KMID : 1036020130020020061
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지질.동맥경화학회지
2013 Volume.2 No. 2 p.61 ~ p.67
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The Inflammation Markers According to the Presence of Coronary Artery Disease in Patients with Peripheral Artery Disease
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Kim Sook-Young
Kang Won-Yu
Youn Bo-Ram
Jung Il-Hyung
Nam Dong-In
Kang Chung
An Hong-Ju
Lee Sang-Sun
Song Ho-Yeong
Kang Hoon
Cho Sang-Cheol
Hwang Sun-Ho
Kim Wan
Shin Jun-Ho
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Abstract
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Objective: Prevalence of coronary artery disease (CAD) has been reported to be high in patients with atherosclerotic peripheral artery disease (PAD) in lower extremities. Various inflammatory markers have been known to be associated with CAD. The aim of study was to explore the role of inflammatory makers for CAD in patients with PAD.
Methods: A total of 346 PAD patients (71.51±9.41 years, 337 males) who underwent percutaneous transluminal angioplasty from June 2006 to April 2012 were included in this study. Patients were divided into the Group I (PAD with CAD: n=151, 149 males) and the Group II (PAD without CAD: n=195, 188 males).
Results: Among 346 patients, 149 patients had CAD (43.6%). The prevalence of diabetes mellitus (DM) (p=0.023) and smoking (p=0.010) were significantly higher in the group I when compared withthe group II. The level of high sensitivity C-reactive protein (hs-CRP) increased (p<0.001) significantly in the group I compared with the group II. By multiple logistic regression analysis, smoking (odds ratio [OR]=1.991, 95% confidence interval [CI]: 1.162-3.411; p=0.012), DM (OR=1.922, 95% CI: 1.145-3.228; p=0.015), hs-CRP (≥3.0 mg/dL) (OR=2.595, 95% CI: 1.548-4.350, p<0.001), and age (OR=0.645; 95% CI, 0.454-0.915; p=0.014) were independent predictors for the development of CAD in PAD patients.
Conclusion: 43.6% of patients with PAD also had CAD, and the predictors of CAD were smoking, DM, and high level of hs-CRP
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KEYWORD
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Coronary artery disease, Peripheral arterial disease, Diabetes mellitus, Inflammation, Smoking
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